The Unknown

I prefer the unknown.

This is pretty simple. Pretty clear. This occurred to me the other day. I couldn’t think of an exception.

Sure, I like to know. I like having knowledge. I’m not a proponent of staying ignorant. I respect knowledge of others.

I am drawn to, I see, I prefer to put myself into the unknown.

I like learning what I haven’t known before.

I seek new people.

I seek new experience.

I seek unfamiliar points of view.

In my work, I operate large amidst the unknown. New ideas. New business models. Unknown markets. Unknown threats. Unknown skills. Unknown rewards.

Startup expertise and negotiating power

  • Agenda: self-promotion
  • subject: expertise as a source of power
  • scenario: startup negotiating for expertise

Every startup founder – and their original team – goes into the world mostly not knowing anything about their “business”.

Many of them are acutely aware of their lack of expert knowledge. In response, they seek expertise outside the firm to supplement their team’s capabilities. To fill the “gaps” in their knowledge.

This seeking help, support, is a sign of self-awareness, a key trait of leaders and terms that can get better.

One consequence for founders and teams of this acutely felt ignorance of “business” knowledge is unconfidence. In a way, this lack of confidence is a positive quality: signifying self-awareness, healthy, durable self-esteem, modesty and respect for others’ distinctive value.

So, why am I writing? What’s my point? To praise mature adults?

I see this, and it doesn’t serve the team, not their nascent business’ future strength: the founder’s unconfidence …

Orbital Mechanics, drawing by Tim Makepeace

Agenda: share a great work of art
Artist: Tim Makepeace
Medium: acrylic on paper

Orbital Mechanics: Galactic Center of Mass- 9 stars v.2
sumi ink, acrylic on paper 49″ x 49″, 2020
By Tim Makepeace bit.ly/31bjt6z

Galactic Center of Mass- 9 stars v.2 sumi ink, acrylic on paper 49″ x 49″, 2020

The Science of discovering Nature’s biosynthetic pathways: colchicine in the flame lily

Agenda: Share inventive, determined scientific experimentation

Whitehead Institute
July 2020 Monthly Roundup
wi.mit.edu
In the News: How the flame lily synthesizes a therapeutic natural product
Read a commentary in Nature by Institute Member Jing-Ke Weng on new research from Elizabeth Sattely’s lab at Stanford on how plants synthesize the medicinal compound colchicine and how this could help engineer organisms to produce colchicine more efficiently.

This flame lily is not a model plant like Arabidopsis thaliana or rice. Little is known about its genetic make-up, and no tools were available that would enable convenient genetic manipulations and analysis. Finding the gene set for colchicine biosynthesis in the total complement of G. superba genes was therefore like finding a needle in a haystack. This is a common problem for plant researchers

Nature Magazine July 22 2020
How the flame lily synthesizes a therapeutic natural product
Jing-Ke Weng
https://www.nature.com/articles/d41586-020-01675-0
Figure 1 | Part of the biosynthetic pathway of colchicine. https://media.nature.com/lw800/magazine-assets/d41586-020-01675-0/d41586-020-01675-0_18192722.png
DOI: 10.1038/d41586-020-01675-0
The discovery of the biosynthetic pathway for colchicine, a medicine produced by plants, holds promise for the use of metabolic-engineering approaches in producing reliably high yields of this compound.

My Keywords:
colchicine
Biochemistry
Plant sciences
colchicine biosynthesis
flame lily Gloriosa superba
autumn crocuses Colchicum autumnale
specialized metabolic enzymes
1-phenethylisoquinoline
biosynthetic pathway
N-formyldemecolcine
plant biosynthesis
metabolically engineered organisms
arthritis
inflammatory diseases
microtubules
crop plant breeding
stereocentre
enantiomers
enantioselective synthesis
phenol-ring coupling
unprecedented molecular ring expansion reaction
tissue-specific transcriptomics data
metabolomics data
methyltransferases
cytochrome P450 enzymes
Nicotiana benthamiana
benth benthi
agro-infiltration
phenylalananine
tyrosine
activity-guided fractionation
transgenes

Nature Magazine Indexed Subjects:
Biochemistry https://www.nature.com/subjects/biochemistry
Plant sciences https://www.nature.com/subjects/plant-sciences

New Deal: New Bets

FDR did make a “deal” with the American people, that’s true and the name, “New Deal”, is apt.*

I ask, How did he do the supporting programs and reforms that were his side of his deal with Americans? The dynamic and trade-offs of the deal he struck are interesting. And why they worked is interesting history of policy and political science. But more interesting to me is how he manifested the outcomes he promised to deliver. You could say my question is, how did he govern? Or a better word, how did he administer?

In large part, the answer is: his administration experimented.

I find the fact that this great reform vision was achieved by – making bets and seeing which ones worked and which ones’ didn’t and calling that his New Deal governing.

In his New York Times Opinion column of July 30, 2020, “The Future of American Liberalism“, David Brooks writes these characterizations of the FDR adminitration:
People … want a leader, like F.D.R., who demonstrates optimistic fearlessness.
…willing to try anything that met the specific emergencies of the moment.
…a wanton willingness to experiment.
…a populist revolt that…F.D.R. …mostly he just outperformed them with talent.
If you want to unleash a torrent of action you have to let individual members of Congress drive their own initiatives…
F.D.R. …was so shifting and pragmatic…
…it’s possible to get a lot done…if you are willing to be…openly experimental.

Notes:

* Stuart Chase, an economist and member of President Franklin D. Roosevelt’s “brain trust” who coined the term “New Deal,” died Saturday [November 16, 1985] … his most famous work, “A New Deal,” published in 1932…

Los Angeles Times Nov. 18, 1985 Chase, Roosevelt Adviser Who Coined Term ‘New Deal,’ Dies https://www.latimes.com/archives/la-xpm-1985-11-18-mn-7307-story.html

All My UXs are in Texas

  • My Agenda: self-promotion
  • My Role: Information architect
  • The Stage of the Business: Mature
  • Who I work with: CEO & the team
  • How they found me and engaged me: Word-of-mouth

One current client engaged me to provide information architecture advice to it’s client.

The client’s site has a vast number of pages, as well as vast numbers of other sorts of files – mainly written reports, articles, and booklets in PDF form.

They see themselves as a resource. And one implied meaning there is: they are place to go to DO something, take action, make progress. Get what you need.

Pitching to any old investor

This week I attended a set of pitches for capital to investors. Anyone was invited to attend, not just registered investors.

I’ve been working with a number of startups – including helping them prepare their pitch for investors.

I studied this week’s performances with an eye to how they are different from and similar to those I’m helping draft.

Use of Cookies and Other Technologies

Hewlett Packard

https://www8.hp.com/us/en/privacy/use-of-cookies.html

We use and allow select partners to use cookies, clickstream capture, pixels, web beacons, web collection forms and other similar technologies (collectively “Automatic Data Collection Tools”) on our HP Services. We do this to understand your use of our HP Services; improve your user experience and enable personalized features and content; optimize our advertisements and marketing; and to enable third-party advertising companies to assist us in serving ads specific to your interests across the Internet.

You can find more information about these technologies at: www.allaboutcookies.org.

ONLINE AUTOMATIC DATA COLLECTION TOOLS

When you visit any HP website, it may store or retrieve information on your browser, mostly in the form of cookies. This information might be about you, your preferences or your device and is mostly used to make the site work as you expect it to and can give you a more personalized web experience.

HP uses Automatic Data Collection Tools for the following reasons:

Strictly Necessary Tools: These are necessary for the website to function and cannot be switched off. Without these, the website or service you are requesting would be impossible to provide essential functionalities (like checkout) or display appropriate content based on the type of device you are using.

Performance and Analytics Tools: These tools collect aggregated, anonymous, statistical-type information to enable HP to measure, optimize and improve the content, quality and performance of its websites. 

We use our own and/or third-party Automatic Data Collection Tools to see how you use our websites and services in order to enhance their performance and develop them according to the preferences of our customers and visitors. For example, Automatic Data Collection Tools may be used to: test different designs and to ensure that we maintain a consistent look and feel across our websites; track and provide trend analysis on how our users interact with our websites and communications; track errors and measure the effectiveness of our promotional campaigns. We use third party tools to track website usage and activity, for example but not limited to Adobe Analytics & Google Analytics. 

The data collected will generally be aggregated to provide trends and usage patterns for business analysis, site/platform improvement and performance metrics. Our Automatic Data Collection Tools or the resulting analysis may be also shared with our business partners. The type of information we collect includes how many visitors visit our websites, how many customers log in, when they visited, for how long and which areas of our websites and services but is generally not used to identify you individually. We may also receive similar information about visitors to our partner websites.

Personalization Tools: These allow us to remember choices you make on our websites (such as your preferred language or the region you are in) and provide enhanced, more personalized features. These technologies are also used to provide content that aligns to your past behavior or interests. 

We also use Automatic Data Collection Tools to change the way our websites behave or look in order to personalize your experience from information we infer from your behavior on our websites or information we may already know about you because, for example, you are a registered customer. These may be used to tailor the services you receive from us or the content, look and feel delivered to you on subsequent sessions to our websites. For example, if you personalize webpages, or register for products or services, Automatic Data Collection Tools help our webpage server recall your specific information. When you next visit our websites, the information you previously provided can be retrieved, so you can easily use the website features that you previously chose. If you use more than one device or computer on a regular basis, we may link Automatic Data Collection Tools together so you will still receive a personalized online experience. We can also personalize the information you see based on what we already know about you, so that you spend less time looking for things. With the use of Automatic Data Collection Tools, each visitor to our site can have a web experience which is unique to them.

Targeting Tools: These are set by HP and other third parties (such as select retail or advertising networks) and used to build a profile to deliver targeted advertising off HP websites and applications that is more relevant and useful to you. These may reflect de-identified demographic or other data linked to data you voluntarily have submitted to us (e.g. your email address). 

These also allow us to collect data related to the HP site and page you visited and your activities on the HP site. As an example, if you visited one of our product pages, via the use of cookies, we may retarget you across partner sites with additional offers and promotions for a certain period of time. 

You can find out more about some of our interest- based advertising partners by visiting these websites:

  • https://www.doubleclickbygoogle.com/
  • http://www.oracle.com/us/legal/privacy/marketing-cloud-data-cloud-privacy-policy/index.html
  • https://www.adobe.com/privacy/marketing-cloud.html
  • https://www.google.com/policies/technologies/ads/

Please note that the above is not an exhaustive list and may be updated by us from time to time. 

If you are a registered user, the information collected from our websites is not anonymous and we may use this information along with other information we know or infer about you including your preferences to tailor content, services, advertising and offers for you. 

Automatic Data Tools that are Strictly Necessary, and third-party technologies used for Performance & Analytics or Personalization are set to expire after the industry standard 2 years. Automatic Data Collection Tools used for targeting are set to expire after 90 days since your last visit. 

When you share information using a social media sharing button on HP websites, the social network will record that you have done this. This information may be linked to targeting/advertising activities. The types of tools used by these third parties and how they use the information generated by them will be governed by those companies’ privacy policies. 

When you visit HP sites, you have the option to accept or adjust what categories of cookies you allow us to place on your browser through our Privacy Preference Centre. You can modify these settings at any time by visiting Cookie Settings

If you don’t want to allow cookies at all, please refer to your browser settings. Note that by disabling certain categories of cookies, you may be prevented from accessing some features of our sites or certain content or functionality may not be available. Certain browsers allow you to navigate websites in an incognito or private mode. Once the browser session is closed, typically all cookies collected during the session are automatically destroyed. 

Even if you opt-out of Performance & Analytics tracking and Targeting, you might continue to see non-personalized advertisements from HP via our partners. As an example, you might visit a website containing Personal Computer feature comparisons. Based on your interest, our partners might serve you with HP product advertisements. 

In the US and Canada, we comply with the Digital Advertising Alliance industry standards with respect to interest based advertising. To learn more about your advertising choices if you are in the US, please click here [http://www.aboutads.info/choices/] or in Canada please click here [http://www.youradchoices.ca/]. In the US, the Network Advertising Initiative also offers a means to opt out of a number of advertising cookies. Please visit www.networkadvertising.org to learn more. Note that opting out does not mean you will no longer receive online advertising. It does mean that the company or companies from which you opted out will no longer deliver ads tailored to your web preferences and usage patterns. 

Some web browsers incorporate “Do Not Track” features. Currently, no industry standard exists for handling “Do Not Track” requests, therefore at this time, our websites may not respond to “Do Not Track” requests or headers from these browsers.

HP ADS AND OFFERINGS ON THIRD-PARTY WEBSITES

HP contracts with service providers to place ads on websites owned by third parties. Sometimes this will be achieved by sharing some personal data as described in the section on Third-Party Advertising Cookies and Social Media Cookies. [https://www8.hp.com/us/en/privacy/privacy.html?pd4=1#What_Data_We_Collect]

In addition, we use and may allow ad networks and other third parties to use cookies and other Automated Data Collection Tools to determine how you interact with our websites, communications and services and selected partner websites and to identify your interests, create profiles and interest segments in order to provide advertising that is most relevant and useful to you.

SHARING WITH PARTNERS

Based on your consent through our cookie settings, HP may share targeting cookie data with select partners for the purposes of audience selection and advertisement. You can change your cookie settings at any time through our cookie settings tool.

End User License Agreement

Hewlett Packard

https://support.hp.com/us-en/document/c00581401

Rev. 10/06 356369-001

PLEASE READ CAREFULLY: THE USE OF SOFTWARE AVAILABLE AT THIS SITE IS SUBJECT TO THE TERMS AND CONDITIONS THAT FOLLOW. IF YOU AGREE TO THESE TERMS, PLEASE CHOOSE THE “I ACCEPT” OPTION LOCATED ADJACENT TO THE SCREEN WHERE THIS AGREEMENT IS DISPLAYED. IF YOU DO NOT AGREE TO THESE LICENSE TERMS, PLEASE CHOOSE THE “I DO NOT ACCEPT” OPTION AND DO NOT DOWNLOAD ANY SOFTWARE FROM THIS SITE.PLEASE READ CAREFULLY BEFORE USING THIS EQUIPMENT: This End-User license Agreement (“EULA”) is a legal agreement between (a) you (either an individual or a single entity) and (b) HP Inc. (“HP”) that governs your use of any Software Product, installed on or made available by HP for use with your HP product (“HP Product”), that is not otherwise subject to a separate license agreement between you and HP or its suppliers. Other software may contain a EULA in its online documentation. The term “Software Product” means computer software and may include associated media, printed materials and “online” or electronic documentation. An amendment or addendum to this EULA may accompany the HP Product.RIGHTS IN THE SOFTWARE PRODUCT ARE OFFERED ONLY ON THE CONDITION THAT YOU AGREE TO ALL TERMS AND CONDITIONS OF THIS EULA. BY INSTALLING, COPYING, DOWNLOADING, OR OTHERWISE USING THE SOFTWARE PRODUCT, YOU AGREE TO BE BOUND BY THE TERMS OF THIS EULA. IF YOU DO NOT ACCEPT THESE LICENSE TERMS, YOUR SOLE REMEDY IS TO RETURN THE ENTIRE UNUSED PRODUCT (HARDWARE AND SOFTWARE) WITHIN 14 DAYS FOR A REFUND SUBJECT TO THE REFUND POLICY OF YOUR PLACE OF PURCHASE.1. GRANT OF LICENSE. HP grants you the following rights provided you comply with all terms and conditions of this EULA:a. Use. You may use the Software Product on a single computer (“Your Computer”). 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The transfer may not be an indirect transfer, such as a consignment. Prior to the transfer, the end user receiving the transferred product must agree to all the EULA terms. Upon transfer of the Software Product, your license is automatically terminated.b. Restrictions. You may not rent, lease or lend the Software Product or use the Software Product for commercial timesharing or bureau use. You may not sublicense, assign or transfer the license or Software Product except as expressly provided in this EULA.5. PROPRIETARY RIGHTS. All intellectual property rights in the Software Product and user documentation are owned by HP or its suppliers and are protected by law, including but not limited to United States copyright, trade secret, and trademark law, as well as other applicable laws and international treaty provisions. You shall not remove any product identification, copyright notices or proprietary restrictions from the Software Product.6. LIMITATION ON REVERSE ENGINEERING. You may not reverse engineer, decompile, or disassemble the Software Product, except and only to the extent that the right to do so is mandated under applicable law notwithstanding this limitation or it is expressly provided for in this EULA.7. TERM. This EULA is effective unless terminated or rejected. This EULA will also terminate upon conditions set forth elsewhere in this EULA or if you fail to comply with any term or condition of this EULA.8. NOTICE OF DATA COLLECTION. You agree that HP and its affiliates may collect, combine, and use device and individual user information you provide in relation to support services related to the Software Product. HP agrees not to use this information to market to you without your consent. Learn More about HP data collection practices at www.hp.com/go/privacy.9. DISCLAIMER OF WARRANTIES. 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You represent that you are of the legal age of majority in your state of residence and, if applicable, you are duly authorized by your employer to enter into this contract.14. APPLICABLE LAW. This EULA is governed by the laws of the State of California, U.S.A. 15. ENTIRE AGREEMENT. This EULA (including any addendum or amendment to this EULA which is included with the HP Product) is the entire agreement between you and HP relating to the Software Product and it supersedes all prior or contemporaneous oral or written communications, proposals and representations with respect to the Software Product or any other subject matter covered by this EULA. To the extent the terms of any HP policies or programs for support services conflict with the terms of this EULA, the terms of this EULA shall control.© 2003, 2018 HP Development Company, L.P. The information contained herein is subject to change without notice. All other product names mentioned herein may be trademarks of their respective companies. The only warranties for HP products and services are set forth in the express warranty statements accompanying such products and services. Nothing herein should be construed as constituting an additional warranty. HP shall not be liable for technical or editorial errors or omissions contained herein. Rev. 10/06 356369-001

IT Certifications that no one questions

My agenda: attention. readers. lip service. clients.

My method: Lure people to my site with brief comments on a durable topic.

I remain skeptical of certificates of training sold to students. To whom shall we grant authority to set a standard regarding what someone needs to know to preform their work to a predetermined level of quality.

This last week I joined a lively discussion of the market value – and recognition – of Agile certifications. So, when I happened upon this article (well, really clickbait, let’s be frank), I decided to comment on it and publish excerpts for self-serving ends.

CIO Magazine June 12, 2020
Top 15 certifications in demand for 2020
By Sarah K. White, Senior Writer, CIO
https://www.cio.com/article/3562331/top-15-certifications-in-demand-for-2020.html

IT certifications can help you quickly gain and validate valuable skills and know-how in a domain that will further your career. Here are the most popular IT certs today.

Top 15 certifications in demand for 2020 by Sarah K. White, Senior Writer, CIO Magazine, June 12, 2020 https://www.cio.com/article/3562331/top-15-certifications-in-demand-for-2020.html

15 most in demand certifications for 2020

  • AWS Certified Solutions Architect
  • Certified Data Professional (CDP)
  • Certified Ethical Hacker
  • Certified ScrumMaster
  • Cisco Certified Internetwork Expert (CCIE)
  • Cisco Certified Network Associate (CCNA)
  • Cisco Certified Network Professional (CCNP)
  • Certified Information Systems Auditor (CISA)
  • CompTIA A+
  • Global Information Assurance Certification (GIAC)
  • Microsoft Certified Solutions Associate (MCSA)
  • Microsoft Technology Associate (MTA)
  • Oracle Certified Professional (OCP)
  • Project Management Professional (PMP)
  • Salesforce Certified Development Lifecycle and Deployment Designer